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Single-use bioreactor : ウィキペディア英語版 | Single-use bioreactor
A single-use bioreactor or ''disposable bioreactor'' is a bioreactor with a disposable bag instead of a culture vessel. Typically, this refers to a bioreactor in which the lining in contact with the cell culture will be plastic, and this lining is encased within a more permanent structure (typically, either a rocker or a cuboid or cylindrical steel support). Commercial single-use bioreactors have been available since the end of the 1990s and are now made by several well-known producers (See below) . == Single-use technology at bioreactors == Single-use bioreactors are widely used in the field of mammalian cell culture and are now rapidly replacing conventional bioreactors. Instead of a culture vessel made from stainless steel or glass, a single-use bioreactor is equipped with a disposable bag. The disposable bag is usually made of a three-layer plastic foil. One layer is made from Polyethylene terephthalate or LDPE to provide mechanical stability. A second layer made using PVA or PVC acts as a gas barrier. Finally, a contact layer is made from PVA or PP. For medical applications the single-use materials that contact the product must be certified by the European Medicines Agency or similar authorities responsible for other regions.
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